Villanova was no match for the heavy favorites, as North Carolina defeated the Wildcats 83-69 on their way to the National Championship for a matchup against Michigan State. The decisive victory was made possible by Ty Lawson's 22 points, Wayne Ellington’s 20 points, and Tyler Hansbrough 18 points and 11 rebounds. Although Villanova fell short of repeating their performance in the 1985 Tournament, they did post a respectable 30-8 record for the season.

With only 5.5 seconds left in the game, Pittsburgh's Levance Fields made two free throws to tie the game 76-76. Moments later, Villanova's Scottie Reynolds took the ball the length of the court for the game winner to advance the Wildcats to the Final Four.

Villanova handed Duke its fifth straight Sweet 16 loss during a 77-54 blowout. Duke leapt to a 5-0 lead, however Villanova quickly caught up and never looked back. The Wildcats posted a tournament record 14th victory over a higher seeded team, with the help of Dante Cunningham's 14 points and 11 rebounds. Villanova went on to the Elite Eight where they beat Pittsburgh in a nail-biter.

Four spectacular alley-oops, a flurry of early 3-pointers, and stellar play from Brandon Rush and Russell Robinson proved too much for Villanova to handle in a 72-57 win that propelled Kansas into the later rounds, including their first National Championship in 20 years.

In this OT battle, Villanova defeated Boston College 60-59 after a critical goaltending call with just seconds left in the game. Randy Foye's 29 points led the top seeded Wildcats to the Elite Eight for a matchup against Florida.

Led by Joakim Noah's 21 points and a career high 15 rebounds, Florida defeated the top-seeded Villanova Wildcats 75-62. Villanova's Randy Foye tried to keep the game close with 25 points, however Florida picked up speed in the middle of the second half and never looked back. The win set them up for another win in the Final Four against George Mason, and ultimately a win in the final game of the season.

North Carolina held off Villanova in the final seconds in a 67-66 nail biter that advanced the top-seeded Tarheels to the Elite Eight for the first time since 2000. Despite the loss, Randy Foye gave his best effort and led the Wildcats' offense with a career-high 28 points.