In a decisive 70-57 win, Duke rolled past Purdue on their way to the Elite Eight for the first time since 2004. Duke's Kyle Singler finished a solid night with 24 points, while Purdue's JaJuan Johnson posted a respectable effort as well with 23 points. The Blue Devils went on to defeat Baylor and move one steps closer to becoming the 2010 national champions.

Connecticut led the whole way during a 72-60 win over the Boilermakers. UCONN's Hasheem Thabeet, the Big East co-player of the year, posted his 18th double-double of the season, with 15 points and 15 rebounds. This win earned the Huskies a spot in the Elite Eight and a chance to move deeper into the later rounds.

With 11.5 seconds left in the game, Purdue's Carson Cunningham sank an off-balance 3-pointer to bring the Boilermakers to within three points. However, Mike Kelley sealed the game moments later with a clutch free throw. This was the deepest the Badgers had gone into the tournament since they won the title back in 1941. Wisconsin went on to meet the eventual national champs Michigan State in a low scoring 53-41 game.

Jaraan Cornell scored 18 points and grabbed seven rebounds as Purdue advanced to the Elite Eight with a 75-66 victory over Gonzaga. Casey Calvary scored 20 points for Gonzaga, however, it was the No.4 seed Boilermakers who dominated the inside with 20 offensive rebounds and 23 second-chance points to send Purdue to the next round where they took on Wisconsin.