Kemba Walker's 23 points led the Huskies past Missouri 82-75 on their way to their 3rd Final Four appearance. The outcome of the game was particularly surprising, as Missouri was just coming off a game where they scored an amazing 102 points, while UCONN was dealing with recent reports of alleged recruiting violations.

Missouri outscored Memphis in a 102-91 shootout to earn a spot in the Elite Eight. Tyreke Evans, with 33 points on the day, led Memphis' valiant comeback attempt after trailing by 24 points early in the second half. However at the end of the day, it was Missouri's offense that carried them to victory and a chance to move on and square off against UConn.

The Sooners advanced to their first national semifinal berth since 1988 with an 81-75 victory over 12th-seeded Missouri. Hollis Price ended the night with 18 points, including two free throws in the last six seconds of the game that sealed the Sooners' 12th straight victory. Missouri's Rickey Paulding and Kareem Rush kept the game close by shooting a combined total of 40 points, however, Oklahoma ultimately earned a spot in the Final Four where they took on Indiana.

12th-seeded Missouri took out UCLA after a comeback effort midway through the second half when Kareem Rush and Clarence Gilbert hit a flurry of 3-pointers to put the Tigers ahead for good. Gilbert finished with 23 points and Rush with 20, as the Tigers set their sights on the Elite Eight for a matchup against Oklahoma.