UCLA's defense continued its dominance during a 59-45 win over LSU. UCLA ended 10 years of tournament disappointment with the help of Luc Richard Mbah a Moute's 17 points and 9 rebounds. Hoping to clinch their 12th national title, UCLA advanced to the NCAA Championship where they squared off against Florida.

LSU outlasted Texas in OT to win it 70-60 and earn their first trip to the Final Four in 20 years. Texas' Daniel Gibson made a 3 pointer in the last thirty seconds to push the game into overtime, however LSU outscored the Longhorns 18-8 in the remaining 5 minutes of OT. Glen Davis led the Tigers to victory and a chance in the Final Four with clutch play and an impressive 26 points.

LSU handed Duke an upset with a 62-54 loss on their way to the later rounds. Shelden Williams posted solid numbers with 23 points and 13 rebounds, however LSU's stingy defense kept the other Blue Devils in check, and thus earning a spot in the Elite Eight where they beat Texas by ten.

Wisconsin's potent offense and smothering defense allowed the Badgers' improbable run through the tournament to continue after a 61-48 victory over LSU. Wisconsin's defense held the Tigers to their lowest point total of the season and more than 27 points below their season average. The Badgers went on to the Elite Eight where they beat Purdue in a close one.