North Carolina made tournament history with their 99th NCAA Tournament victory in a decisive 98-77 win over Gonzaga. Ty Lawson set the tone early on with 17 points in the first half. Tyler Hansbrough's 24 points and 10 rebounds added more fuel to the fire as North Carolina cruised to the Regional Finals to square off against Oklahoma.

UCLA scored 11 points and a comeback victory in the final :20 against Gonzaga. Despite Adam Morrison's 24 points and an offense that dominated UCLA for most of the game, Gonzaga could not stop the Bruin's last minute heroics. UCLA's went on to win two more games until finally losing to Florida in the National Championship.

Michigan State muscled its way to a decisive 77-62 win over the Gonzaga Bulldogs. The Spartans out-rebounded the Bulldogs 47-28 while Charlie Bell and Andre Hutson shot a combined 40 points. The Bulldogs headed home after making their third straight appearance in the Sweet 16, while Michigan State went on to the Final Four after beating Temple in the Elite Eight.

Jaraan Cornell scored 18 points and grabbed seven rebounds as Purdue advanced to the Elite Eight with a 75-66 victory over Gonzaga. Casey Calvary scored 20 points for Gonzaga, however, it was the No.4 seed Boilermakers who dominated the inside with 20 offensive rebounds and 23 second-chance points to send Purdue to the next round where they took on Wisconsin.